POC5

Across TCGA cell cohorts, POC5 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible POC5-associated genes across cancer lineages are MS4A4A, TAFA1, and OR6B3. Each is linked with POC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both POC5-to-partner and partner-to-POC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A4A grouped by POC5-low versus POC5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POC5→partner) and Y-score (partner→POC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MS4A4A →	+0.182	+3.000	<.001	.006	3	1
LARGE_INTESTINE	TAFA1 →	+0.234	+3.103	.002	.004	3	1
BLOOD_Leukemia	OR6B3 →	+0.019	+4.539	<.001	.007	3	1
BLOOD_Leukemia	TRIM49B →	+0.140	+4.874	<.001	.002	3	1
BLOOD_Leukemia	TMEM114 →	+0.033	+4.539	<.001	.007	3	1
BLOOD_Leukemia	CFHR2 →	+0.296	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MS4A4A by POC5 expression — LARGE_INTESTINE

Explore this box plot interactively →