POC1A

Across TCGA pan-cancer cohorts, POC1A mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated POC1A data layer compared with 28 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher POC1A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated POC1A expression acts as an unfavorable survival marker.

HNSC and UCEC are the cancer types where POC1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.277	0.782	.019	24	view →
UCEC	DFS	Median	All	0.811	0.965	.030	4	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

POC1A–HNSC (DFS)

Open the HNSC breakdown →