POC1A

Across TCGA patient cohorts, POC1A mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POC1A-associated genes across cancer lineages are Notch1, Caspase-7-cleavedD198, and ACC_pS79. Each is linked with POC1A in more than 1 cancer types. Because this analysis shows association rather than direction, both POC1A-to-partner and partner-to-POC1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by POC1A-low versus POC1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POC1A→partner) and Y-score (partner→POC1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.216	+2.820	.005	.035	3	1
UCEC	Caspase-7-cleavedD198 →	+1.193	+3.019	<.001	.019	3	1
UCEC	ACC_pS79 →	+0.499	+2.817	.008	.036	2	1
UCEC	p27_pT198 →	+0.137	+3.169	.019	.020	2	1
UCEC	Cyclin-B1 →	+0.782	+3.169	.011	.020	2	1
UCEC	JNK_pT183_Y185 →	-0.238	-3.156	.009	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Notch1 by POC1A expression — UCEC

Explore this box plot interactively →