POC1A

Across TCGA cell cohorts, POC1A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,798 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible POC1A-associated GO terms across cancer lineages are Spindle elongation, Regulation of mitotic spindle checkpoint, and Attachment of spindle microtubules to kinetochore. Each is linked with POC1A in more than 19 cancer types. Because this analysis shows association rather than direction, both POC1A-to-partner and partner-to-POC1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Spindle elongation grouped by POC1A-low versus POC1A-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POC1A→partner) and Y-score (partner→POC1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Spindle elongation →	+0.249	+0.924	<.001	.001	3	20
URINARY_TRACT	Regulation of mitotic spindle checkpoint →	+0.167	+1.166	<.001	.001	3	19
KIDNEY	Attachment of spindle microtubules to kinetochore →	+0.154	+1.265	<.001	<.001	3	19
URINARY_TRACT	Regulation of spindle checkpoint →	+0.165	+1.166	<.001	.001	3	19
URINARY_TRACT	Regulation of mitotic cell cycle spindle assembly checkpoint →	+0.167	+1.166	<.001	.001	3	19
URINARY_TRACT	Regulation of mitotic sister chromatid separation →	+0.176	+1.127	<.001	.002	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,798 associations by consensus.

Spindle elongation by POC1A expression — SOFT_TISSUE

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