Across TCGA patient cohorts, PNRC2 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNRC2-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and A-Raf_pS299. Each is linked with PNRC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PNRC2-to-partner and partner-to-PNRC2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNRC2→partner) and Y-score (partner→PNRC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.319	-2.700	.004	.006	3	1
UCEC	eIF4E →	+0.226	+3.183	.017	.009	3	1
UCEC	A-Raf_pS299 →	-0.201	-3.169	<.001	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.137	-2.449	.015	.019	3	1
UCEC	GATA6 →	-0.223	-2.577	.001	.011	3	1
UCEC	Heregulin →	-0.179	-3.308	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Exploration

PNRC2 survival (RNA) · tumor vs normal (RNA) · all PNRC2 data types