PNPT1

Across TCGA pan-cancer cohorts, PNPT1 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of PNPT1’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where PNPT1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PNPT1 is over-expressed in tumor, although a few such as CCRCC and PDAC show the opposite, repressed pattern.

CCRCC, COAD, and LSCC are the cancer types where PNPT1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PNPT1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	II,III,IV	−0.655	<.001	11	view →
COAD	Male	III,IV	+0.594	<.001	10	view →
LSCC	Male	All	+0.708	<.001	8	view →
LUAD	Male	II,III,IV	+0.503	<.001	8	view →
PDAC	Female	All	−0.581	<.001	5	view →
HNSC	Male	IV	+0.278	.004	4	view →
OV	All	All	+0.420	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

PNPT1–CCRCC

Open the CCRCC breakdown →