Across TCGA pan-cancer cohorts, PNPP1 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of PNPP1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PNPP1 RNA is repressed in tumor relative to normal tissue. In most cancer types PNPP1 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.

KIRC are the cancer types where PNPP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PNPP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	−0.006	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: PNPP1 RNA expression & survival · all PNPP1 data types