PNPO

Across TCGA pan-cancer cohorts, PNPO Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated PNPO data layer compared with 20 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher PNPO Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PNPO expression acts as an unfavorable survival marker.

ESCA and LIHC are the cancer types where PNPO Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.226	0.686	.013	12	view →
LIHC	OS	Median	All	0.144	0.704	.016	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

PNPO–ESCA (OS)

Open the ESCA breakdown →