PNPO

Across TCGA pan-cancer cohorts, PNPO mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PNPO data layer compared with 20 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PNPO mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PNPO expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where PNPO mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	II,III,IV	0.978	0.085	.027	11	view →
PDAC	OS	Quartile	All	1.000	0.731	.010	7	view →
HNSC	DFS	Quartile	II,III,IV	0.661	0.891	.015	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PNPO–CCRCC (OS)

Open the CCRCC breakdown →