PNPO

Across TCGA pan-cancer cohorts, PNPO mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of PNPO’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where PNPO mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PNPO is over-expressed in tumor, although a few such as CCRCC and PDAC show the opposite, repressed pattern.

CCRCC, PDAC, and LSCC are the cancer types where PNPO tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PNPO mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	III,IV	−0.679	<.001	12	view →
PDAC	All	III,IV	−0.467	<.001	9	view →
LSCC	All	III,IV	−0.401	<.001	9	view →
HNSC	Male	II,III,IV	−0.343	<.001	8	view →
COAD	All	II,III,IV	−0.189	.002	7	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

PNPO–CCRCC

Open the CCRCC breakdown →