PNPO

Across TCGA patient cohorts, PNPO protein abundance is significantly associated with the RNA expression of many other genes, with 15,359 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PNPO-associated genes across cancer lineages are ACSM5, FGD2, and PPIH. Each is linked with PNPO in more than 5 cancer types. Because this analysis shows association rather than direction, both PNPO-to-partner and partner-to-PNPO results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PNPO versus ACSM5 in CCRCC, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNPO→partner) and Y-score (partner→PNPO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ACSM5 →	+1.076	+0.375	.001	<.001	3	6
GBM	FGD2 →	+0.608	+0.239	.002	.006	3	5
BRCA	PPIH →	-0.430	-0.343	.001	<.001	3	5
CCRCC	TCN2 →	+0.988	+0.314	<.001	<.001	3	5
LSCC	MSH6 →	-0.700	-0.245	<.001	.001	3	5
GBM	TUBB →	-0.560	-0.343	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,359 associations by consensus.

PNPO vs ACSM5 — CCRCC

Explore this scatter interactively →