PNPO

Across TCGA cell cohorts, PNPO RNA expression is significantly associated with the go_rna of many other GO terms, with 2,936 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PNPO-associated GO terms across cancer lineages are Vitamin B6 biosynthetic process, Vitamin B6 metabolic process, and Pyridoxal 5'-phosphate metabolic process. Each is linked with PNPO in more than 17 cancer types. Because this analysis shows association rather than direction, both PNPO-to-partner and partner-to-PNPO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vitamin B6 biosynthetic process grouped by PNPO-low versus PNPO-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PNPO→partner) and Y-score (partner→PNPO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Vitamin B6 biosynthetic process →	+0.159	+0.798	<.001	<.001	3	18
LIVER	Vitamin B6 metabolic process →	+0.244	+1.248	<.001	<.001	3	16
URINARY_TRACT	Pyridoxal 5'-phosphate metabolic process →	+0.232	+0.896	<.001	<.001	3	16
BREAST	Aldehyde biosynthetic process →	+0.168	+1.361	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Positive regulation of hematopoietic stem cell proliferation →	+0.104	+0.998	.001	.002	3	9
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair via nonhomologous end joining →	+0.057	+0.922	.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,936 associations by consensus.

Vitamin B6 biosynthetic process by PNPO expression — LUNG_SCLC

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