PNPLA8

Across TCGA pan-cancer cohorts, PNPLA8 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PNPLA8’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where PNPLA8 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PNPLA8 is over-expressed in tumor, although a few such as CCRCC and COAD show the opposite, repressed pattern.

CCRCC, COAD, and LSCC are the cancer types where PNPLA8 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PNPLA8 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	III,IV	−0.541	<.001	12	view →
COAD	Male	All	−0.479	<.001	9	view →
LSCC	All	II,III,IV	−0.214	<.001	8	view →
PDAC	All	All	+0.388	.008	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

PNPLA8–CCRCC

Open the CCRCC breakdown →