PNPLA6

Across TCGA patient cohorts, PNPLA6 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,151 significant associations in total. OV shows the largest number of these associations.

The most reproducible PNPLA6-associated GO terms across cancer lineages are Negative regulation of protein localization to chromatin, Regulation of autophagosome maturation, and Regulation of myeloid leukocyte mediated immunity. Each is linked with PNPLA6 in more than 23 cancer types. Because this analysis shows association rather than direction, both PNPLA6-to-partner and partner-to-PNPLA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of protein localization to chromatin grouped by PNPLA6-low versus PNPLA6-high in UVM.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PNPLA6→partner) and Y-score (partner→PNPLA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	Negative regulation of protein localization to chromatin →	+0.074	+0.517	<.001	<.001	3	24
OV	Regulation of autophagosome maturation →	+0.052	+0.674	<.001	<.001	3	22
LAML	Regulation of myeloid leukocyte mediated immunity →	+0.039	+0.467	<.001	<.001	3	21
UCS	Regulation of neutrophil activation →	+0.069	+0.610	<.001	.002	3	21
MESO	Regulation of T-helper 17 type immune response →	+0.050	+0.746	<.001	<.001	3	20
KICH	Regulation of protein localization to centrosome →	+0.045	+0.787	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,151 associations by consensus.

Negative regulation of protein localization to chromatin by PNPLA6 expression — UVM

Explore this box plot interactively →