PNPLA6

Across TCGA patient cohorts, PNPLA6 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNPLA6-associated genes across cancer lineages are ATM, 4E-BP1, and YAP_pS127. Each is linked with PNPLA6 in more than 4 cancer types. Because this analysis shows association rather than direction, both PNPLA6-to-partner and partner-to-PNPLA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PNPLA6-low versus PNPLA6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNPLA6→partner) and Y-score (partner→PNPLA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.670	-3.169	<.001	.017	3	4
SKCM	4E-BP1 →	+0.535	+3.584	<.001	.002	2	5
LUAD	YAP_pS127 →	-0.462	-3.000	.019	.036	3	3
UCEC	TIGAR →	+0.139	+1.944	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.613	+1.543	<.001	.004	3	3
COAD	Cyclin-B1 →	+0.573	+2.178	.025	.035	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

ATM by PNPLA6 expression — COAD

Explore this box plot interactively →