PNPLA6

Across TCGA cell cohorts, PNPLA6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,333 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PNPLA6-associated GO terms across cancer lineages are Actin filament depolymerization, Regulation of autophagosome maturation, and Calcium-independent cell-matrix adhesion. Each is linked with PNPLA6 in more than 15 cancer types. Because this analysis shows association rather than direction, both PNPLA6-to-partner and partner-to-PNPLA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Actin filament depolymerization grouped by PNPLA6-low versus PNPLA6-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PNPLA6→partner) and Y-score (partner→PNPLA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Actin filament depolymerization →	+0.200	+0.959	<.001	<.001	3	16
SKIN	Regulation of autophagosome maturation →	+0.098	+0.864	<.001	<.001	3	14
BONE	Calcium-independent cell-matrix adhesion →	+0.200	+0.918	<.001	.004	3	13
LIVER	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.114	+1.082	<.001	<.001	2	14
SKIN	Retrograde transport, endosome to Golgi →	+0.087	+0.930	<.001	<.001	3	12
SKIN	Protein depolymerization →	+0.131	+0.841	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,333 associations by consensus.

Actin filament depolymerization by PNPLA6 expression — SKIN

Explore this box plot interactively →