PNPLA6

Across TCGA cell cohorts, PNPLA6 mutation is significantly associated with the RNA expression of many other genes, with 1,356 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PNPLA6-associated genes across cancer lineages are SETD7, MCUB, and PRSS38. Each is linked with PNPLA6 in more than 2 cancer types. Because this analysis shows association rather than direction, both PNPLA6-to-partner and partner-to-PNPLA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SETD7 grouped by PNPLA6-low versus PNPLA6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNPLA6→partner) and Y-score (partner→PNPLA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SETD7 →	+0.709	+3.321	<.001	.002	3	3
LARGE_INTESTINE	MCUB →	+0.849	+2.158	.001	.004	3	3
LUNG_SCLC	PRSS38 →	+0.044	+3.887	<.001	.001	3	2
LARGE_INTESTINE	CCNP →	+1.200	+2.158	<.001	.004	3	2
BLOOD_Leukemia	ELOVL6 →	+1.487	+3.351	.004	.003	3	2
BLOOD_Leukemia	KANK3 →	+1.072	+3.351	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,356 associations by consensus.

SETD7 by PNPLA6 expression — LARGE_INTESTINE

Explore this box plot interactively →