PNPLA3

Across TCGA cell cohorts, PNPLA3 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PNPLA3-associated genes across cancer lineages are TGM7, SI, and CCT4. Each is linked with PNPLA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PNPLA3-to-partner and partner-to-PNPLA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TGM7 grouped by PNPLA3-low versus PNPLA3-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNPLA3→partner) and Y-score (partner→PNPLA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TGM7 →	+0.013	+5.087	<.001	.004	3	1
BLOOD_Lymphoma	SI →	+0.023	+5.643	<.001	.002	3	1
LARGE_INTESTINE	CCT4 →	+0.606	+3.067	.001	.009	3	1
LARGE_INTESTINE	LCT →	+0.461	+3.657	<.001	.001	3	1
LARGE_INTESTINE	CR2 →	+0.774	+3.184	<.001	.007	3	1
LARGE_INTESTINE	SULT6B1 →	+0.021	+2.977	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

TGM7 by PNPLA3 expression — URINARY_TRACT

Explore this box plot interactively →