Across TCGA pan-cancer cohorts, PNP mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PNP data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PNP mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PNP expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and HNSC are the cancer types where PNP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.662	0.424	<.001	79	view →
CCRCC	DFS	Tertile	All	0.908	0.593	<.001	70	view →
HNSC	OS	Median	All	0.928	0.769	.009	19	view →
LUAD	OS	Quartile	III,IV	0.262	0.950	.015	7	view →
LSCC	OS	Quartile	II,III,IV	0.936	0.737	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: PNP tumor-vs-normal RNA expression · all PNP data types