Across TCGA patient cohorts, PNP protein abundance is significantly associated with the RNA expression of many other genes, with 16,407 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible PNP-associated genes across cancer lineages are CHRM2, GPRASP2, and LIFR. Each is linked with PNP in more than 5 cancer types. Because this analysis shows association rather than direction, both PNP-to-partner and partner-to-PNP results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNP→partner) and Y-score (partner→PNP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CHRM2 →	-1.021	-0.288	<.001	<.001	3	6
HNSC	GPRASP2 →	-0.983	-0.405	<.001	<.001	3	6
UCEC	LIFR →	-0.924	-0.370	.001	<.001	3	5
HNSC	ZNF599 →	-0.560	-0.360	<.001	<.001	3	5
HNSC	LIFR-AS1 →	-0.554	-0.416	.001	<.001	3	5
HNSC	MIR2052HG →	-1.081	-0.353	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,407 associations by consensus.

Exploration

PNP survival (RNA) · tumor vs normal (RNA) · all PNP data types