Across TCGA patient cohorts, PNP mutation is significantly associated with the RNA expression of many other genes, with 815 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNP-associated genes across cancer lineages are NMNAT1, RWDD4, and ARMCX3-AS1. Each is linked with PNP in more than 1 cancer types. Because this analysis shows association rather than direction, both PNP-to-partner and partner-to-PNP results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNP→partner) and Y-score (partner→PNP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NMNAT1 →	+0.487	+3.364	.001	.004	3	2
UCEC	RWDD4 →	+0.592	+2.906	.001	.002	3	2
UCEC	ARMCX3-AS1 →	+0.091	+2.510	<.001	.001	3	2
UCEC	LINC01128 →	+0.406	+2.906	<.001	.002	3	2
UCEC	LINC01425 →	+0.078	+2.202	.003	.003	3	2
UCEC	ELOA-AS1 →	+0.574	+4.010	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 815 associations by consensus.

Exploration

PNP survival (RNA) · tumor vs normal (RNA) · all PNP data types