Across TCGA patient cohorts, PNP mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNP-associated genes across cancer lineages are EGFR_pY1068, AMPK_pT172, and Smad4. Each is linked with PNP in more than 1 cancer types. Because this analysis shows association rather than direction, both PNP-to-partner and partner-to-PNP results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNP→partner) and Y-score (partner→PNP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.282	-2.321	.025	.035	3	1
UCEC	AMPK_pT172 →	+0.439	+3.000	.033	.036	3	1
UCEC	Smad4 →	-0.128	-2.321	.035	.035	3	1
UCEC	VHL →	-0.751	-3.459	.027	.005	3	1
UCEC	XBP1 →	-0.197	-2.986	.005	.035	3	1
UCEC	A-Raf_pS299 →	-0.140	-3.321	.019	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

PNP survival (RNA) · tumor vs normal (RNA) · all PNP data types