PNOC

Across TCGA patient cohorts, PNOC RNA expression is significantly associated with the protein abundance of many other proteins, with 20,965 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PNOC-associated proteins across cancer lineages are TXNDC5, SEPTIN6, and HCLS1. Each is linked with PNOC in more than 6 cancer types. Because this analysis shows association rather than direction, both PNOC-to-partner and partner-to-PNOC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PNOC versus TXNDC5 in HNSC, with a Pearson correlation of 0.54.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PNOC→partner) and Y-score (partner→PNOC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TXNDC5 →	+0.680	+0.893	<.001	<.001	3	7
LSCC	SEPTIN6 →	+0.499	+0.873	<.001	<.001	3	7
HNSC	HCLS1 →	+0.567	+0.816	<.001	<.001	3	7
LSCC	HSPA13 →	+0.545	+0.862	<.001	<.001	3	7
PDAC	IGHG1 →	+0.706	+0.622	<.001	<.001	3	7
UCEC	IGHV1-18 →	+0.792	+0.841	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,965 associations by consensus.

PNOC vs TXNDC5 — HNSC

Explore this scatter interactively →