PNOC

Across TCGA patient cohorts, PNOC protein abundance is significantly associated with the RNA expression of many other genes, with 4,059 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PNOC-associated genes across cancer lineages are PRODH, SEZ6L, and SEPTIN3. Each is linked with PNOC in more than 1 cancer types. Because this analysis shows association rather than direction, both PNOC-to-partner and partner-to-PNOC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PNOC versus PRODH in GBM, with a Pearson correlation of 0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNOC→partner) and Y-score (partner→PNOC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRODH →	+0.901	+0.958	<.001	<.001	3	1
GBM	SEZ6L →	+1.387	+0.926	<.001	<.001	3	1
GBM	SEPTIN3 →	+1.094	+1.073	<.001	<.001	3	1
GBM	RASL10A →	+0.721	+1.050	<.001	<.001	3	1
GBM	NEFH →	+1.238	+1.074	<.001	<.001	3	1
GBM	HMOX1 →	-0.784	-0.854	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,059 associations by consensus.

PNOC vs PRODH — GBM

Explore this scatter interactively →