PNOC

Across TCGA cell cohorts, PNOC RNA expression is significantly associated with the go_rna of many other GO terms, with 3,383 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PNOC-associated GO terms across cancer lineages are Proton motive force-driven mitochondrial ATP synthesis, Keratan sulfate proteoglycan metabolic process, and Endodermal cell fate specification. Each is linked with PNOC in more than 4 cancer types. Because this analysis shows association rather than direction, both PNOC-to-partner and partner-to-PNOC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Proton motive force-driven mitochondrial ATP synthesis grouped by PNOC-low versus PNOC-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PNOC→partner) and Y-score (partner→PNOC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Proton motive force-driven mitochondrial ATP synthesis →	+0.070	+1.887	.003	.008	3	5
BLOOD_Lymphoma	Keratan sulfate proteoglycan metabolic process →	-0.085	-2.336	<.001	<.001	3	5
BONE	Endodermal cell fate specification →	+1.712	+3.082	<.001	<.001	3	4
BLOOD_Lymphoma	Positive regulation of defense response to bacterium →	+0.182	+1.765	<.001	.001	3	4
BLOOD_Lymphoma	Viral translational termination-reinitiation →	+0.075	+1.881	.003	.004	3	4
BLOOD_Lymphoma	Response to iron(II) ion →	-0.093	-1.843	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,383 associations by consensus.

Proton motive force-driven mitochondrial ATP synthesis by PNOC expression — OVARY

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