PNO1

Across TCGA patient cohorts, PNO1 mutation is significantly associated with the RNA expression of many other genes, with 202 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNO1-associated genes across cancer lineages are RNA5SP231, MRPL57P6, and AKAP5. Each is linked with PNO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PNO1-to-partner and partner-to-PNO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP231 grouped by PNO1-low versus PNO1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNO1→partner) and Y-score (partner→PNO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP231 →	+0.520	+7.924	<.001	.008	3	2
LUAD	MRPL57P6 →	+0.199	+7.930	<.001	.008	3	1
UCEC	AKAP5 →	+0.565	+3.700	<.001	.001	3	1
UCEC	NOP10 →	+0.452	+3.227	.007	.009	3	1
UCEC	LCK →	+0.829	+2.606	.004	.006	3	1
UCEC	RTP5 →	+0.187	+2.710	.003	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 202 associations by consensus.

RNA5SP231 by PNO1 expression — LUSC

Explore this box plot interactively →