PNO1

Across TCGA patient cohorts, PNO1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNO1-associated genes across cancer lineages are Fibronectin, Shc_pY317, and Bcl-2. Each is linked with PNO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PNO1-to-partner and partner-to-PNO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by PNO1-low versus PNO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNO1→partner) and Y-score (partner→PNO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.344	-2.990	.046	.036	3	1
UCEC	Shc_pY317 →	-0.221	-3.000	.005	.036	3	1
UCEC	Bcl-2 →	+0.397	+2.196	.029	.034	3	1
UCEC	Chk1 →	-0.201	-2.999	.020	.035	3	1
UCEC	Ku80 →	+0.285	+3.009	.021	.019	2	1
UCEC	Src →	-0.283	-3.321	.008	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Fibronectin by PNO1 expression — UCEC

Explore this box plot interactively →