PNO1

Across TCGA cell cohorts, PNO1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,050 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible PNO1-associated GO terms across cancer lineages are Maturation of SSU-rRNA, Ribosomal small subunit biogenesis, and Nucleolar large rRNA transcription by RNA polymerase I. Each is linked with PNO1 in more than 19 cancer types. Because this analysis shows association rather than direction, both PNO1-to-partner and partner-to-PNO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maturation of SSU-rRNA grouped by PNO1-low versus PNO1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PNO1→partner) and Y-score (partner→PNO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Maturation of SSU-rRNA →	+0.136	+0.890	<.001	<.001	3	20
LIVER	Ribosomal small subunit biogenesis →	+0.119	+0.708	<.001	.005	3	19
BONE	Nucleolar large rRNA transcription by RNA polymerase I →	+0.161	+0.796	<.001	.001	3	19
PANCREAS	Maturation of 5.8S rRNA →	+0.111	+1.130	<.001	<.001	3	19
BLOOD_Lymphoma	Transcription by RNA polymerase I →	+0.094	+0.961	<.001	<.001	3	19
BLOOD_Myeloma	Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.112	+0.826	<.001	.004	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,050 associations by consensus.

Maturation of SSU-rRNA by PNO1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →