PNN

Across TCGA pan-cancer cohorts, PNN mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PNN data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PNN mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PNN expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

HNSC, LSCC, and PDAC are the cancer types where PNN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.592	0.902	.001	27	view →
LSCC	OS	Median	II,III,IV	0.892	0.601	.008	11	view →
PDAC	OS	Quartile	II,III,IV	0.398	0.584	.014	8	view →
LUAD	OS	Quartile	II,III,IV	1.000	0.740	.014	6	view →
CCRCC	OS	Quartile	All	0.884	1.000	.015	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PNN–HNSC (OS)

Open the HNSC breakdown →