PNMA8C

Across TCGA patient cohorts, PNMA8C protein abundance is significantly associated with the RNA expression of many other genes, with 2,042 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PNMA8C-associated genes across cancer lineages are CYTH4, SH3BP1, and PIK3IP1. Each is linked with PNMA8C in more than 1 cancer types. Because this analysis shows association rather than direction, both PNMA8C-to-partner and partner-to-PNMA8C results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PNMA8C versus CYTH4 in GBM, with a Pearson correlation of -0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNMA8C→partner) and Y-score (partner→PNMA8C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CYTH4 →	-1.041	-0.524	.002	<.001	3	1
GBM	SH3BP1 →	-0.488	-0.442	<.001	<.001	3	1
GBM	PIK3IP1 →	-0.864	-0.560	.002	<.001	3	1
GBM	GCAT →	+0.487	+0.324	.004	.003	3	1
GBM	CRYBB1 →	-1.051	-0.617	<.001	<.001	3	1
GBM	AP1B1 →	-0.712	-0.442	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,042 associations by consensus.

PNMA8C vs CYTH4 — GBM

Explore this scatter interactively →