PNMA8A

Across TCGA pan-cancer cohorts, PNMA8A Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PNMA8A data layer compared with 26 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PNMA8A Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PNMA8A expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, UCEC, and LIHC are the cancer types where PNMA8A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.161	0.696	.006	48	view →
UCEC	DFS	Median	III,IV	1.000	0.538	.032	18	view →
LIHC	OS	Median	All	0.028	0.775	<.001	12	view →
COAD	OS	Median	III,IV	0.147	0.546	.021	12	view →
ESCA	OS	Median	II,III,IV	0.277	0.686	.026	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PNMA8A–HNSC (DFS)

Open the HNSC breakdown →