Across TCGA pan-cancer cohorts, PNMA6E RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PNMA6E’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where PNMA6E RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PNMA6E is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

BRCA, HNSC, and KIRC are the cancer types where PNMA6E tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PNMA6E RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	Female	II,III,IV	+0.099	.028	4	view →
HNSC	All	All	+0.276	.028	2	view →
KIRC	Male	All	−0.032	<.001	2	view →
KICH	Female	II,III,IV	−0.042	.002	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: PNMA6E RNA expression & survival · all PNMA6E data types