PNMA6B

Across TCGA patient cohorts, PNMA6B RNA expression is significantly associated with the go_rna of many other GO terms, with 5,278 significant associations in total. COAD shows the largest number of these associations.

The most reproducible PNMA6B-associated GO terms across cancer lineages are Mitochondrion-endoplasmic reticulum membrane tethering, Transport along microtubule, and Positive regulation of TOR signaling. Each is linked with PNMA6B in more than 5 cancer types. Because this analysis shows association rather than direction, both PNMA6B-to-partner and partner-to-PNMA6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrion-endoplasmic reticulum membrane tethering grouped by PNMA6B-low versus PNMA6B-high in COAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PNMA6B→partner) and Y-score (partner→PNMA6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Mitochondrion-endoplasmic reticulum membrane tethering →	+0.022	+0.058	<.001	<.001	3	6
PCPG	Transport along microtubule →	+0.014	+0.394	.001	<.001	3	5
COAD	Positive regulation of TOR signaling →	+0.019	+0.049	<.001	.002	3	5
PAAD	Endothelial cell chemotaxis →	+0.031	+0.202	<.001	<.001	2	6
COAD	Amyloid-beta clearance by transcytosis →	+0.036	+0.051	<.001	.001	3	5
COAD	Eye morphogenesis →	+0.020	+0.087	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,278 associations by consensus.

Mitochondrion-endoplasmic reticulum membrane tethering by PNMA6B expression — COAD

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