PNMA6A

Across TCGA patient cohorts, PNMA6A mutation is significantly associated with the RNA expression of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNMA6A-associated genes across cancer lineages are TBX22, CRISP1, and TRDJ4. Each is linked with PNMA6A in more than 1 cancer types. Because this analysis shows association rather than direction, both PNMA6A-to-partner and partner-to-PNMA6A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBX22 grouped by PNMA6A-low versus PNMA6A-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNMA6A→partner) and Y-score (partner→PNMA6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	TBX22 →	+0.018	+5.219	<.001	.006	3	1
READ	CRISP1 →	+0.041	+5.653	<.001	.003	3	1
READ	TRDJ4 →	+0.732	+5.653	<.001	.003	3	1
READ	RPL23AP4 →	+0.164	+5.039	<.001	.008	3	1
READ	MIR548T →	+0.733	+5.653	<.001	.003	3	1
READ	RN7SKP192 →	+0.162	+5.653	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

TBX22 by PNMA6A expression — READ

Explore this box plot interactively →