PNMA6A

Across TCGA cell cohorts, PNMA6A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,085 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PNMA6A-associated GO terms across cancer lineages are Aldosterone biosynthetic process, Potassium ion transmembrane transport, and Primary alcohol biosynthetic process. Each is linked with PNMA6A in more than 10 cancer types. Because this analysis shows association rather than direction, both PNMA6A-to-partner and partner-to-PNMA6A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Aldosterone biosynthetic process grouped by PNMA6A-low versus PNMA6A-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PNMA6A→partner) and Y-score (partner→PNMA6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Aldosterone biosynthetic process →	+1.930	+2.514	<.001	<.001	3	11
OVARY	Potassium ion transmembrane transport →	-0.034	-0.758	.009	.001	3	11
LIVER	Primary alcohol biosynthetic process →	-0.378	-1.637	<.001	.006	2	11
BONE	RNA splicing, via transesterification reactions →	+0.076	+1.575	<.001	<.001	3	10
BONE	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.094	+1.998	<.001	<.001	3	10
BONE	mRNA splicing, via spliceosome →	+0.094	+1.998	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,085 associations by consensus.

Aldosterone biosynthetic process by PNMA6A expression — BONE

Explore this box plot interactively →