Across TCGA cell cohorts, PNMA5 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PNMA5-associated genes across cancer lineages are ACTRT2, MC2R, and SPPL2C. Each is linked with PNMA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PNMA5-to-partner and partner-to-PNMA5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNMA5→partner) and Y-score (partner→PNMA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ACTRT2 →	+0.064	+4.922	.001	.009	3	1
BLOOD_Leukemia	MC2R →	+0.006	+5.969	<.001	.001	3	1
BLOOD_Leukemia	SPPL2C →	+0.012	+4.922	<.001	.009	3	1
BLOOD_Leukemia	SLC22A12 →	+0.006	+5.539	<.001	.003	3	1
BLOOD_Leukemia	KRTAP12-3 →	+0.079	+5.539	<.001	.003	3	1
BLOOD_Leukemia	USP17L3 →	+0.029	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

PNMA5 survival (RNA) · tumor vs normal (RNA) · all PNMA5 data types