Across TCGA patient cohorts, PNMA3 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNMA3-associated genes across cancer lineages are ASNS, ATM, and c-Myc. Each is linked with PNMA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PNMA3-to-partner and partner-to-PNMA3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNMA3→partner) and Y-score (partner→PNMA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.436	+1.847	<.001	.007	3	2
UCEC	ATM →	-0.362	-1.247	.019	.045	3	2
UCEC	c-Myc →	-0.206	-1.861	.014	.049	3	2
UCEC	EGFR_pY1068 →	-0.299	-2.137	<.001	.001	3	1
UCEC	A-Raf_pS299 →	-0.131	-1.514	.001	.015	3	1
UCEC	ACC1 →	+0.262	+1.713	.034	.024	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Exploration

PNMA3 survival (RNA) · tumor vs normal (RNA) · all PNMA3 data types