Across TCGA cell cohorts, PNMA3 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PNMA3-associated genes across cancer lineages are GSTA5, C9orf92, and GZMK. Each is linked with PNMA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PNMA3-to-partner and partner-to-PNMA3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNMA3→partner) and Y-score (partner→PNMA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GSTA5 →	+0.035	+4.930	<.001	.008	3	1
SOFT_TISSUE	C9orf92 →	+0.194	+5.369	<.001	.004	3	1
BLOOD_Leukemia	GZMK →	+0.352	+3.359	.008	.002	3	1
BLOOD_Leukemia	GTSF1L →	+0.536	+3.619	.001	.007	3	1
BLOOD_Leukemia	HMHB1 →	+2.114	+3.619	.003	.007	3	1
BLOOD_Leukemia	LMX1A →	+0.133	+3.239	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Exploration

PNMA3 survival (RNA) · tumor vs normal (RNA) · all PNMA3 data types