PNMA2

Across TCGA patient cohorts, PNMA2 mutation is significantly associated with the RNA expression of many other genes, with 2,268 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNMA2-associated genes across cancer lineages are MIR4457, RARRES2P2, and MIR4772. Each is linked with PNMA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PNMA2-to-partner and partner-to-PNMA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4457 grouped by PNMA2-low versus PNMA2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNMA2→partner) and Y-score (partner→PNMA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR4457 →	+0.348	+4.496	<.001	.007	3	2
READ	RARRES2P2 →	+0.158	+4.280	<.001	.007	3	2
READ	MIR4772 →	+0.603	+4.421	<.001	.009	3	2
BRCA	TRDD1 →	+0.545	+7.057	<.001	.009	3	2
UCEC	PPP6R2 →	+0.306	+3.008	.004	<.001	3	2
UCEC	MCAT →	+0.337	+2.815	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,268 associations by consensus.

MIR4457 by PNMA2 expression — LUSC

Explore this box plot interactively →