PNMA2

Across TCGA patient cohorts, PNMA2 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNMA2-associated genes across cancer lineages are eIF4E, PDCD4, and cIAP. Each is linked with PNMA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PNMA2-to-partner and partner-to-PNMA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PNMA2-low versus PNMA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNMA2→partner) and Y-score (partner→PNMA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.200	+2.070	.006	.001	3	2
UCEC	PDCD4 →	-0.436	-2.459	.007	.018	3	2
UCEC	cIAP →	+0.107	+2.125	.024	.010	3	2
UCEC	eIF4G →	+0.267	+3.321	.013	.009	3	1
UCEC	FoxM1 →	+0.226	+2.009	.011	.017	3	1
UCEC	FOXO3a_pS318_S321 →	-0.116	-2.415	.007	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

eIF4E by PNMA2 expression — UCEC

Explore this box plot interactively →