PNMA2

Across TCGA cell cohorts, PNMA2 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PNMA2-associated genes across cancer lineages are CCT8L2, IL3, and TMPRSS11B. Each is linked with PNMA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PNMA2-to-partner and partner-to-PNMA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCT8L2 grouped by PNMA2-low versus PNMA2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNMA2→partner) and Y-score (partner→PNMA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CCT8L2 →	+0.006	+5.289	.006	<.001	3	2
URINARY_TRACT	IL3 →	+0.020	+4.087	<.001	.009	3	1
URINARY_TRACT	TMPRSS11B →	+0.047	+4.217	.003	.005	3	1
URINARY_TRACT	MAGEE2 →	+0.005	+4.087	<.001	.009	3	1
URINARY_TRACT	KRTAP19-4 →	+0.145	+4.087	<.001	.009	3	1
URINARY_TRACT	OPTC →	+0.031	+4.217	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

CCT8L2 by PNMA2 expression — BLOOD_Leukemia

Explore this box plot interactively →