PNMA2

Across TCGA cell cohorts, PNMA2 mutation is significantly associated with the mutation status of many other genes, with 926 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PNMA2-associated genes across cancer lineages are TMEM132D, NUTM1, and RUSC2. Each is linked with PNMA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PNMA2-to-partner and partner-to-PNMA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM132D grouped by PNMA2-low versus PNMA2-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNMA2→partner) and Y-score (partner→PNMA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TMEM132D →	+4.672	+4.672	.001	.001	1	3
BLOOD_Leukemia	NUTM1 →	+3.285	+3.662	.004	.004	1	3
BLOOD_Leukemia	RUSC2 →	+2.870	+3.347	.009	.009	1	3
BLOOD_Leukemia	CAMTA2 →	+3.963	+4.662	<.001	<.001	1	3
LARGE_INTESTINE	P3H1 →	+2.459	+3.321	.005	.005	1	3
LARGE_INTESTINE	PMFBP1 →	+2.611	+4.372	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 926 associations by consensus.

TMEM132D by PNMA2 expression — OESOPHAGUS

Explore this box plot interactively →