PNMA1

Across TCGA patient cohorts, PNMA1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. COAD shows the largest number of these associations.

The most reproducible PNMA1-associated genes across cancer lineages are c-Met_pY1235, Mre11, and Stathmin. Each is linked with PNMA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PNMA1-to-partner and partner-to-PNMA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by PNMA1-low versus PNMA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNMA1→partner) and Y-score (partner→PNMA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.078	+2.000	.019	.032	3	2
COAD	Mre11 →	+0.150	+2.815	.021	.036	3	2
COAD	Stathmin →	+0.302	+2.820	<.001	.035	3	2
UCEC	ACC1 →	+0.395	+2.000	.015	.032	3	1
UCEC	MEK1 →	+0.403	+2.459	.014	.019	3	1
UCEC	Notch1 →	+0.240	+3.331	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

c-Met_pY1235 by PNMA1 expression — UCEC

Explore this box plot interactively →