PNLIP

Across TCGA pan-cancer cohorts, PNLIP Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PNLIP data layer compared with 14 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PNLIP Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated PNLIP expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, ACC, and CESC are the cancer types where PNLIP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.618	.005	34	view →
ACC	DFS	Median	All	0.093	0.674	<.001	33	view →
CESC	DFS	Median	III,IV	0.053	0.729	<.001	18	view →
LIHC	DFS	Median	II,III,IV	0.080	0.427	.019	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PNLIP–UCEC (DFS)

Open the UCEC breakdown →