PNLIP

Across TCGA patient cohorts, PNLIP mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNLIP-associated genes across cancer lineages are Rab11, ACC1, and CD31. Each is linked with PNLIP in more than 2 cancer types. Because this analysis shows association rather than direction, both PNLIP-to-partner and partner-to-PNLIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rab11 grouped by PNLIP-low versus PNLIP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNLIP→partner) and Y-score (partner→PNLIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rab11 →	-0.146	-2.087	.008	.005	3	3
LUSC	ACC1 →	+0.517	+2.331	.006	.019	3	2
LUSC	CD31 →	-0.214	-3.000	.005	.033	3	2
UCEC	PCNA →	+0.216	+2.087	.009	.005	3	2
UCEC	S6_pS240_S244 →	+0.366	+1.678	.018	.023	3	2
UCEC	ASNS →	+0.625	+2.700	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Rab11 by PNLIP expression — UCEC

Explore this box plot interactively →