PNLIP

Across TCGA cell cohorts, PNLIP mutation is significantly associated with the RNA expression of many other genes, with 196 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PNLIP-associated genes across cancer lineages are MYF6, OPRPN, and MTRNR2L10. Each is linked with PNLIP in more than 1 cancer types. Because this analysis shows association rather than direction, both PNLIP-to-partner and partner-to-PNLIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYF6 grouped by PNLIP-low versus PNLIP-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNLIP→partner) and Y-score (partner→PNLIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MYF6 →	+1.059	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OPRPN →	+0.030	+4.887	.005	.009	3	1
LUNG_NSCLC_LUAD	MTRNR2L10 →	+0.013	+6.266	<.001	<.001	3	1
LARGE_INTESTINE	GDAP1 →	+0.974	+3.212	.002	.006	3	1
LARGE_INTESTINE	CARD8 →	+0.614	+3.212	.004	.006	3	1
LARGE_INTESTINE	CLCN3 →	+0.749	+3.212	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 196 associations by consensus.

MYF6 by PNLIP expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →