PNLDC1

Across TCGA patient cohorts, PNLDC1 mutation is significantly associated with the RNA expression of many other genes, with 4,404 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNLDC1-associated genes across cancer lineages are PPIAL4F, ZNHIT3, and MIR4530. Each is linked with PNLDC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PNLDC1-to-partner and partner-to-PNLDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPIAL4F grouped by PNLDC1-low versus PNLDC1-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNLDC1→partner) and Y-score (partner→PNLDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	PPIAL4F →	+0.059	+3.554	.009	.002	3	3
UCEC	ZNHIT3 →	+0.481	+2.557	<.001	<.001	3	3
CESC	MIR4530 →	+0.741	+3.783	.004	.005	3	3
UCEC	BLOC1S6 →	+0.510	+2.233	<.001	<.001	3	3
UCEC	KCTD9 →	+0.642	+2.269	<.001	<.001	3	3
UCEC	FUBP3 →	+0.411	+1.700	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,404 associations by consensus.

PPIAL4F by PNLDC1 expression — READ

Explore this box plot interactively →