PNLDC1

Across TCGA patient cohorts, PNLDC1 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNLDC1-associated genes across cancer lineages are EGFR_pY1068, mTOR_pS2448, and C-Raf_pS338. Each is linked with PNLDC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PNLDC1-to-partner and partner-to-PNLDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PNLDC1-low versus PNLDC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNLDC1→partner) and Y-score (partner→PNLDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.250	-2.247	.002	.001	3	3
UCEC	mTOR_pS2448 →	-0.159	-2.643	.001	<.001	3	3
BLCA	C-Raf_pS338 →	-0.161	-2.999	.016	.035	3	2
UCEC	FoxM1 →	+0.176	+1.652	.038	.006	3	2
UCEC	p21 →	+0.158	+3.472	.012	.002	3	2
UCEC	Shc_pY317 →	-0.145	-1.938	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

EGFR_pY1068 by PNLDC1 expression — UCEC

Explore this box plot interactively →