PNLDC1

Across TCGA cell cohorts, PNLDC1 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PNLDC1-associated genes across cancer lineages are RSPH6A, ENPP6, and NPHS2. Each is linked with PNLDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PNLDC1-to-partner and partner-to-PNLDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RSPH6A grouped by PNLDC1-low versus PNLDC1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNLDC1→partner) and Y-score (partner→PNLDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RSPH6A →	+0.027	+3.874	<.001	.006	3	2
BLOOD_Leukemia	ENPP6 →	+0.316	+3.345	.003	.009	3	2
LARGE_INTESTINE	NPHS2 →	+0.075	+3.444	.001	.003	3	1
LARGE_INTESTINE	TKTL2 →	+0.046	+4.509	<.001	<.001	3	1
LARGE_INTESTINE	TRHR →	+0.041	+2.906	.003	.008	3	1
LARGE_INTESTINE	OR13D1 →	+0.022	+3.297	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

RSPH6A by PNLDC1 expression — CNS

Explore this box plot interactively →