PNKP

Across TCGA pan-cancer cohorts, PNKP Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PNKP data layer compared with 21 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher PNKP Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PNKP expression acts as an unfavorable survival marker.

SCLC, HNSC, and LIHC are the cancer types where PNKP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	II,III,IV	0.137	0.700	<.001	36	view →
HNSC	OS	Median	All	0.156	0.710	.002	24	view →
LIHC	OS	Median	All	0.061	0.777	<.001	12	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PNKP–SCLC (OS)

Open the SCLC breakdown →